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*After antioxidant activity, oxidized Vitamin E is reduced by Vitamin C, and oxidized Vitamin C is reduced by glutathione

Notably, a prescription that identifies only a patients name and drug product formulation is not sufficient to establish that the prescriber made the determination that the formulation would produce a significant difference from the commercially available drug product. According to the guidance, appropriate justification and documentation might include the following: No Dye X, patient allergy (if the comparable drug contains the dye) Liquid form, patient cant swallow tablet (if the comparable drug is a tablet) 6 mg, patient needs higher dose (if the comparable drug is only available in 5 mg dose)