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however, residual confounding by baseline BMI, glycemic status, indication, and discontinuation timing remains difficult to exclude ( 4.5.2 Early pregnancy exposure: risk characterization under limited data Existing registry, cohort, and systematic-review data have not identified a stable pattern of major structural malformations after brief early-pregnancy exposure to GLP-1RAs, but the exposed human evidence base remains limited and heterogeneous

At entry patients reported a mean weight loss of 12 2,5 (SEM) kg

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It was shown that liraglutide clarify protection against hypoxia by activating the MAPK and PI3K/AKT pathways in vivo and in vitro against ischemic damage (107)