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In May 1995, NTBC was designated an Orphan Drug by the Office for Orphan Product Development

These findings suggest that levels of AngIV in the brain potentially plays a role in the development of Alzheimers disease [1]

On the other hand, melatonin dysregulation in bipolar disorder may be caused by light-sensitive melatonin suppression and delayed melatonin secretion [10]

Estimation of APAP levels in serum using high-performance liquid chromatography (HPLC) To confirm obtaining toxic levels, an estimation of the APAP level in serum was performed