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Various ion channels are implicated in the transduction of sour taste such as the epithelial Na + channel (ENaC), the polycystic kidney disease protein 1 like 3 (PKD1L3) and PKD2L1 or the inwardly rectifying K + channel (KIR2.1) [42434445]

Healthcare providers can assess the overall benefit-risk profile and determine the most appropriate course of action based on individual patient circumstances, therapeutic goals, and tolerance patterns