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Portion Tip: Start with just a tablespoon

GLP-1 medications work by mimicking a naturally occurring hormone that your intestines release after eating

In the landmark STEP 1 trial, published in the New England Journal of Medicine , 1,961 adults with a BMI of 30 or greater (or 27 or greater with comorbidities) were randomized to receive once-weekly subcutaneous semaglutide 2.4 mg or a placebo, alongside a lifestyle intervention

Why Might Mood Changes Happen

While experiences vary, the growing discussion around GLP-1 microdosing reflects a broader shift toward more personalized approaches to metabolic healthones that prioritize comfort, consistency, and long-term support rather than one-size-fits-all solutions