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When you administer Melanotan-2 at 5001000 mcg and PT-141 at 12 mg within the same 6-hour window, you're saturating the same receptor population twice

Light pressure with a clean cotton ball or gauze is fine if there is minor bleeding, but vigorous rubbing can spread the medication away from the intended depot and may increase bruising

The fasting requirement (empty stomach, no food or water for 30 minutes) makes it inconvenient

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Its mechanism involves modulation of the hypothalamic-pituitary-adrenal (HPA) axis, regulation of cortisol and growth hormone-releasing hormone (GHRH) secretion, and interaction with the GABAergic and glutamatergic systems