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Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study

Over time, persistent follicular inflammation contributes to progressive miniaturization and, in its most severe expression, irreversible fibrosis of the follicular unit

Physiologic replacement of both these incretin agents in the form of dual GLP-1/GIP receptor activating compounds (twincretins) has yielded encouraging results vis--vis glucose and body weight regulation

But until the research catches up, and regulation does, too, the risks belong entirely to the user and those risks are not completely theoretical

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