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42 Ferroptosis is initiated by the depletion of GSH, leading to the inactivation of GPx4, a key enzyme that protects against lipid peroxidation

Animal studies place the plasma half-life at approximately 2 hours after subcutaneous injection

Transdermal routes often struggle with penetration in a predictable way

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To optimize clinical efficacy, a precise strategy, inhibition or activation, must be judiciously selected on the basis of the specific disease, its stage, and the role of LONP1