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When stratified by administration route, the average percentage reductions were: Intramuscular (IM): 48.3% Sublingual: 30.7% Oral: 30.3% These results suggest that IM administration leads the most pronounced homocysteine reduction, however, sublingual and oral routes also demonstrate clinically relevant effects

For parenteral use only after admixture with suitable medication

Hydroxocobalamin is a long-acting B12 used for deficiency with less frequent dosing

Semaglutide, the latter emerges as the preferred option

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