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That said, there isnt really a downside to doubling the dose of this supplement to achieve that greater HMB dose and see an uptick in creatine consumption, other than the increased expense.7 You also get 5mg of BioPerine per dose, a branded black pepper fruit extract thats been shown to increase nutrient absorption in numerous studies looking at various ingredients.21 Its unclear how much it would influence that HMB dose, though its highly doubtful that it would double the efficacy
Funding This work was supported by the National Key R&D Program of China (grant number: 2023YFC3404100, 2023YFC2506400), and National Natural Science Foundation of China (grant number: 82325042, 82203860), and Shanghai Municipal Education Commission Scientific Research Innovation Project (grant number: 2023-05-50), Wu Jieping Medical Foundation Research Project (grant number: 32067502023-18-29)
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Furthermore, we also show neuroprotection and motor improvement in an in vivo mouse model of neurodegeneration 18
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