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In the Phase 2 obesity trial (Jastreboff et al., New England Journal of Medicine , 2023), investigators reported dose-dependent mean weight reduction of up to 17.5% at 24 weeks and up to 24.2% at 48 weeks

It could also have some effect on lipid parameters, which, together with the above, may reduce cardiovascular morbidity and mortality.31 Learning and memory Studies in mice support the use of CoQ10 for cognition and memory, though human trials are few and far between.13 Pulmonary function Patients with chronic lung disease performed better at several exercise metrics in a study that employed a 90mg CoQ10 dose over eight weeks.14 Migraines In a meta-analysis of six studies, CoQ10 reduced the frequency and duration of migraine attacks, though it didnt have an effect on attack severity.15 Fertility Some of the best evidence supporting CoQ10s use in fertility comes from this review involving women undergoing fertility treatments, in which doses ranging from 180mg to 1,200mg resulted in more successful pregnancies than placebo.16 Men may also see a fertility benefit, with evidence suggesting that a 200mg dose is sufficient to significantly improve semen parameters.32 Because CoQ10 production declines with age, supplementation simply replaces the CoQ10 that would otherwise be there