For context, tirzepatide 15 mg in the SURMOUNT trials had discontinuation rates around 6-7%
Bianchi R, Cervellini I, Porretta-Serapiglia C, Oggioni N, Burkey B, Ghezzi P et al (2012) Beneficial effects of PKF275-055, a novel, selective, orally bioavailable, long-acting dipeptidyl peptidase IV inhibitor in streptozotocin-induced diabetic peripheral neuropathy
[DOI] [PMC free article] [PubMed] [Google Scholar] 32.Kulle A, Li Z, Kwak A, Mancini M, Young D, Avizonis DZ, Groleau M, Baglole CJ, Behr MA, King IL, Divangahi M, Langlais D, Wang J, Blagih J, Penz E, Dufour A, and Thanabalasuriar A
What is the main difference between cagrilintide and retatrutide
Adding keto to this combination is generally manageable but may be unnecessary, given that three separate appetite-suppressing interventions could reduce intake to dangerously low levels