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3 Chemoresistance-induced mitochondrial function in ALs Mitochondria allow metabolic adaptation to various stress conditions as they are an integrating center of important cellular processes that include energy production through OxPhos, redox signaling, anabolic and catabolic reactions, epigenetic regulation, cell self-renewal and differentiation, initiation, and run-time programmed cell death (PCD) (Guerra et al., 2017