retatrutide triple hormone receptor agonist obesity mechanism of action Research Guide: What the Phase 2 Trial Data Reported (2026) Triple–Hormone-Receptor Agonist Retatrutide for Obesity

NNMT permanently removes NAM by transferring the methyl group from S-adenosyl methionine (SAM) to NAM to produce meNAM and S-adenosyl-l-homocysteine (SAH) 57

4 When it's disrupted, constipation gets worse

You may know them by their generic pharmaceutical names, like semaglutide, or their commercial brand names like Ozempic or Wegovy (FYI: both Ozempic and Wegovy are brand names for semaglutide, but the drugs are approved and formulated to treat different conditions, so they get different names

In mice, treatment with a probiotic strain of Bifidobacterium elevated plasma levels of this hormone [108]

and the red cross denotes receptor antagonism