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Semaglutide delivers 14.9% body weight loss in STEP-1 (4,500+ patients)

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1 Introduction Despite decades of intensive research and substantial investmentwith Alzheimers disease alone projected to surpass 1 trillion USD in global cost by 2050 (Nandi et al., 2024), therapeutic progress in neurodegenerative disorders has remained limited, with most clinical approaches continuing to target downstream proteinopathies and yielding only modest effects on disease trajectories (Selkoe and Hardy, 2016

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Future studies are needed to determine if there is a benefit in NASH reduction or fibrosis regression