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Sensitivity analyses including MR Egger regression, weighted median, weighted mode (both weighted and simple), maximum likelihood, and RAPS yielded consistent results, thereby reinforcing our causal inferences

The first report on GLP1RArelated reduction in alcohol intake in humans was a conference abstract from 2011 [79]

Trends show 30 million people will be trying GLP-1s by 2030up to 10% of the population

The appetite-suppressing effects could be beneficial for some individuals struggling with binge eating disorder, helping to regulate food intake

Second, the rules shifted recently: after the FDA declared the semaglutide shortage resolved in early 2025, the special allowances that let pharmacies widely compound semaglutide were phased out over that year