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Moreover, in hepatocellular carcinoma (HCC), antiangiogenic tyrosine kinase inhibitors (TKIs) are effective therapeutic agents and the main therapeutic effect is to induce severe hypoxia in the tumor microenvironment (TME) through depletion of the vascular density of tumor

Mol Neurobiol 50(1):246256 Ambrogini P, Albertini MC, Betti M et al (2018) Neurobiological correlates of alpha-tocopherol antiepileptogenic effects and microRNA expression modulation in a rat model of kainate-induced seizures [J]

Therefore, further investigation into the relationship between histone-related genes and BIPN is warranted

To escape from this dead end, we need faster development of new, mechanism-based therapies