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My recommendations for maximizing topical GHK-Cu, in addition to my suggestion you read the GHK-Cu dosage guide I put together, are as follows: Use a pharmaceutical-grade topical formulation Apply immediately after microneedling to drive penetration into the dermis Combine with a low-level red light therapy or photobiomodulation session to enhance local cellular response Systemic GHK-Cu via subcutaneous injection is a different beast entirely