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insulin dose at GLP-1RA initiation was only decreased if HbA1c was below 7.5% ( Our current practice is to consider a ~20% bolus insulin decrease and a ~10% basal insulin decrease before GLP-1RA initiation, although prior A1c, risk of hypoglycemia, potential risk of ketosis due to reduced insulin doses, as well as other patient-specific factors should guide the final insulin dose changes

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Reactive Oxygen Species Measurements The activity of ROS was detected using the DCFH-DA kit (S0033, Beyotime) following the manufacturer's guidebook