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Other cautions include: History of pancreatitis or gallbladder disease Certain gastrointestinal disorders Pregnancy or breastfeeding Specific allergy or sensitivity to semaglutide Common side effects can include nausea, vomiting, diarrhea, constipation, abdominal discomfort, and fatigue, especially during dose escalation

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In the same cohort, semaglutide improved MASH-related SomaSignal profiles, which are aptamer-based proteomic profiles associated with MASH components [6]