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experts again attribute this to rapid loss of local fatty tissue, not direct drug action on genital organs. Broader coverage has grouped Ozempic penis with phenomena such as Ozempic hands (bony, veiny hands after fat loss) and skin laxity, all understood as consequences of rapid and substantial weight reduction. This pattern supports the view that GLP1 therapies remodel body contours by changing fat distribution rather than directly reshaping genital anatomy

It signals the body to hold onto muscle tissue even as overall body weight decreases

Liu J et al

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Rhythm Pharma is modulating the MC4R and POMC pathways in rare genetic (congenital) forms of obesitythough this work may not translate beyond these populations