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Results: Effect size for desire: 0.49 to 0.61 Effect size for distress reduction: 0.60 to 0.62 25% of treated patients versus 17% placebo achieved clinically meaningful desire increase 35% versus 31% achieved clinically meaningful distress reduction A 52-week open-label extension confirmed sustained efficacy and safety (PMC6819021, PMC6819023)

Tagrisso (osimertinib) Disease area(s): Oncology Manufacturer(s): AstraZeneca 2024 Sales (USD): $6.58 billion Why it sold so well: In 2024, AstraZenecas EGFR-TKI Tagrisso registered $6.58 billion in global sales, reflecting a 13% year-over-year increase

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