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In the Billon 2023 paper, mice given 30 mg/kg IP still showed measurable plasma and muscle concentrations at 6 hours post-injection, which helps explain why twice-daily dosing was used in efficacy studies

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We observed significantly decreased brain activity and functional connectivity with rs-fMRI

Hernndez-Montoliu L, Rodrguez-Pea M-M, Puig R, Astiarraga B, Guerrero-Prez F, Virgili N, Lpez-Urdiales R, Osorio J, Monseny R, Lazzara C et al (2023) A specific gut microbiota signature is associated with an enhanced GLP-1 and GLP-2 secretion and improved metabolic control in patients with type 2 diabetes after metabolic Roux-en-Y gastric bypass

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