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Exposure to hypoxia at high altitude (5380 m) for 1 year induces reversible effects on semen quality and serum reproductive hormone levels in young male adults

Cardiovasc Hematol Disord Drug Targets 2014

Its therapeutic value lies in its ability to selectively induce apoptosis in senescent cells by disrupting the FOXO4-p53 interactome, a mechanism that evades the collateral cytotoxicity often seen with broader senolytics like Navitoclax (Huang et al., 2021)

Both in vitro and ex vivo studies have shown that Th1 cells exhibit greater susceptibility to AICD than Th2 cells, a difference largely attributed to more efficient Fas ligand surface expression in Th1 cells, which in turn contributes to the Th2-biased immune profile observed in AD (Oberg et al., 1997

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