semaglutide and spleen Glucagon-Like Peptide 1 Receptor Agonists for Obesity: Efficacy, Side Effects, Risks | Current Treatment Options in Gastroenterology Semaglutide GLP-1 Weight Loss Injections

This is often not a failure of the treatment itself, but rather a sign that the active ingredients have degraded past the point of efficacy

Reproductive and obesity medicine experts tell USA TODAY that theyre also noticing the trend in their offices, and it boils down to two main reasons

As a GLP-1 receptor agonist, it mimics the hormone glucagon-like peptide-1, which your body naturally releases after eating

Clinical trials consistently show tirzepatide produces about 5% more body weight loss than semaglutide, likely due to this dual mechanism

With semaglutide, reducing the dose predictably reduces GLP-1 activity across the board