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A 2012 meta-analysis, in fact, demonstrated that on average patients with ASD had a 27% lower plasma concentration of GSH with corresponding 45% higher plasma levels of reduced GSH (GSSG) when compared to health controls (127)

Such doses in humans would be fatal and one would expect the same in C

As the most cytotoxic aldehyde [76], 4-HNE is an , -unsaturated aldehyde and a highly reactive lipid-derived electrophile [77]

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However, there are no medical guidelines about who might benefit from coffee enemas, and more research is necessary to understand the possible benefits