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In contrast, it was found that the spontaneous and KCl-evoked release of glutamate in the prefrontal cortical synaptosomes was suppressed by thiopental and it reduced the extracellular level of glutamate in the rat prefrontal cortex (Hongliang and Shanglong, 2004

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These initial studies reported increased NAD + and NAM levels in plasma, and in urine, the excreted NAD + levels increased after 6 h 66 , but it must be noted that these trials utilized small cohorts and short testing periods, and only a minor trend for cognitive improvement was observed 117

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