In addition to AD, alterations in intracellular zinc homeostasis are considered a critical factor in the development of PD
While its molecular mechanisms remain incompletely understood, ferroptosis plays a critical role in disease pathogenesis, including cancer, neurodegenerative disorders, and ischemia-reperfusion injury ( Despite substantial progress in elucidating the role of ferroptosis in disease, its interplay with pathogen infections has been relatively understudied
It is generally believed that TNF-, IL-6, and leptin are involved in iron metabolism by regulating the hepcidin expression in obesity
Recently, a key finding uncovered SLC25A51 as a mitochondrial transporter for intact NAD + in human cell lines 78,79
Those most at risk include vegans, vegetarians, seniors, and people with digestive conditions that affect nutrient absorption