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The selectivity difference is studied to distinguish pigmentation pathways (MC1R) from central appetite and sexual function pathways (MC4R) in research models

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doi: 10.1053/j.gastro.2003.08.033 50 IaniroG.TilgH.GasbarriniA

In particular, Ras mutations induce dysregulated cell division within thyroid follicular cells, leading to hyperplastic thyroid lesions including nodules (Peterson 2014)