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With COMT being responsible for methylating 2-Hydroxyestradiol (2-HE) into 2-ME, it has been demonstrated that low activity or expression of this enzyme could be involved in the pathogenesis of preeclampsia (82)

Members of the transient receptor potential C (TRPC) family of cation channels are Ca 2+ -permeable and were suggested to be involved [90]

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Oligodendrocytes can metabolically support axons by providing monocarboxylates, classically discussed as lactate, but potentially also pyruvate, to sustain axonal energy demands

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