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Green tea extracts (particularly EGCG), berberine, and certain polyphenols from foods like cinnamon and turmeric have demonstrated modest modulating effects in research

Liraglutide-induced weight loss is blunted by the local injection of a GLP-1R antagonist into the ARC [2]

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Moving from peptide-based biologics to small molecules like orforglipron redefines scalability, simplifies supply chains, and expands global reach