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By delaying the rate at which food exits the stomach, semaglutide extends the postprandial period during which satiety hormones like GLP-1 and peptide YY remain elevated, suppressing the ghrelin rebound that typically triggers hunger 90120 minutes after eating

Delivery optimization : For localized conditions like OA, intra-articular GLP-1RA delivery may achieve higher local concentrations with less systemic exposure, representing a precision medicine opportunity

doi: 10.1016/S0140-6736(12)61350-6

*Correspondence: Soliman Mohammadi-Samani, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

28 Currently, the clinical and safety implications of these alterations in calcitonin levels are unknown