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It has been reported that acetaminophen injection led to a significant release of intracellular iron and subsequent ROS accumulation by activating ferritinophagy on the one hand and inhibiting the endogenous nuclear factor E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) antioxidant pathway on the other hand, which contributes to clear intracellular ROS
Lipid peroxidation and iron metabolism: two corner stones in the homeostasis control of ferroptosis
doi: 10.1016/S0167-4781(00)00026-9 52 LippaA
Chin Med J (Engl)
A naturally occuring triterpene saponin ardisiacrispin B displayed cytotoxic effects in multi-factorial drug resistant cancer cells via ferroptotic and apoptotic cell death
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