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8,9 Greater HbA 1c reduction with Toujeo vs degludec was also seen in the propensity score matched sensitivity analysis (p=0.02) 1 Key Observations Second Generation vs First Generation Basal Insulins: Second-generation basal insulins were more effective in improving glycemic control when added to or replacing therapy in patients already on GLP-1 receptor agonists (GLP-1 RA)

It can also lead to issues such as headaches, dizziness, lethargy, and constipation

Finally, it is also important to note that vaccinations with AstraZeneca (viral vector, genetically modified virus vaccine) and Pfizer (mRNA vaccine), but not Sinopharm (inactivated virus vaccine), may aggravate the neuropsychiatric symptoms and, in particular, the somatic symptoms of HAMA and HAMD

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