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Available at: (Accessed December 18, 2024)

and Beckman, J.S

Directly supplementing with oral reduced glutathione (L-GSH), however, presents a fundamental pharmacokinetic challenge: GSH has a plasma half-life of approximately 1.6 minutes, undergoes rapid hydrolysis in the gut by intestinal -glutamyl transpeptidase (-GT), and cannot cross cell membranes intact requiring full breakdown into constituent amino acids and intracellular resynthesis

Graphical Abstract Similar content being viewed by others Introduction Immunomodulation is transforming the treatment landscape of type 1 diabetes [1, 2]

Overall the area-under-curve in the cochlea was higher, while blood and organ exposure was lower