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Its level decreases with age (especially from the age of 45-50) and as the body's defence needs increase (immunity, liver detoxification, antioxidant defences...)
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Wang S, Shi M, Zhou J, Wang W, Zhang Y, Li Y Circulating exosomal mir-181b-5p promoted cell senescence and inhibited angiogenesis to impair diabetic foot ulcer via the nuclear factor erythroid 2-related factor 2/Heme oxygenase-1 pathway
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