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3 The first report of a clinical picture consistent with what nowadays is termed SS was in 1960, 4 which described the coadministration of L-tryptophan (the substrate of the rate-limiting enzyme, tryptophan hydroxylase [TPH], in the biochemical synthesis of serotonin) with a monoamine oxidase inhibitor (MAOI) inducing delirium

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Completion of a fixed ratio 10 (FR10) schedule of reinforcement on the appropriate lever activated a dipper that presented 0.1 mL of sucrose (10% w/v) and illuminated the cue light above the lever for 4 seconds

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