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In a rat hemorrhagic model of acute anemia, transfusion of anaerobically stored RBCs was superior to that of conventional RBCs in that a lower RBC volume was required in order to normalize hemodynamics (mean arterial blood pressure), a study endpoint chosen because of its adoption in clinical guidelines for trauma management including those for Advanced Trauma Life Support and from the American College of Surgeons (Williams et al., 2020)

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Over time, it can lead to additional health problems and complications