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"Triple-Hormone-Receptor Agonist Retatrutide for Obesity." NEJM 2023;389:514526 FDA Prescription Drug User Fee Act (PDUFA) Guidelines FDA Center for Drug Evaluation and Research (CDER): NDA review process ClinicalTrials.gov: TRIUMPH Phase 3 program trial registry Historical obesity drug approval precedents: Semaglutide, Tirzepatide, Liraglutide Frequently Asked Questions Based on the current timeline, retatrutide FDA approval is expected in late 2027 to Q1 2028

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By slowing digestion and signaling fullness, they reduce cravings and make portion control easier

doi: 10.1001/jama.257.17.2297 143 HellingerWCSmithTFVan ScoyRESpitzerPGForgacsPEdsonRS