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They also had to participate in dietary counseling, and their doctor needed to attest they were increasing their physical activity

Some patients benefit from a brief pause in dose escalation to allow further adaptation

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They defined hyperhomocysteinemia as severe for concentrations higher than 100 mol/L, intermediate for concentrations between 30 and 100 mol/L, and moderate for concentrations of 15 to 30 mol/L, and a reference total plasma homocysteine range as 5 to 15 mol/L (mean, 10 mol/L)