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For example, obese patients given 500 mg thrice daily for 12 weeks achieved significant improvements: 5 lbs weight loss and a 23% reduction in triglycerides with a 12% drop in total cholesterol

Pharmacological and methodological considerations

Despite significantly lower potency compared to clinically used AChE inhibitors, the studied peptides represent a promising scaffold for further optimization

WB and chromatin immunoprecipitation (ChIP) analyses revealed that p53 overexpression can target and negatively regulate biological activity by binding to the SLC7 A11 promoter [35], indicating that p53 can mediate ferroptosis through multiple pathways at the same time