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& Dionisi-Vici, C

This duration of safety monitoring provides meaningful reassurance about sustained exposure effects that would not be apparent in brief trials

But there were performance benefits too (see figure 2): During 30 minutes of exercise at 50% VO2max (mild intensity), the carnitine group were using 50% less glycogen during exercise ( ie more from fat oxidation) by the 24th week of loading compared to the control group

A meta-analysis reported modest overall craving reductions (Hedges' g approximately -0.48 across 12 RCTs, n=681) with high heterogeneity (I-squared greater than 70%) and publication bias risks [37]

doi: 10.1038/s41467-020-14959-w 5 ArvanitakisZ.CapuanoA