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Indeed, unlike other thiols, homocysteine incubation with endothelial cells induces an increased expression of the stress protein GRP78 and a decreased expression of glutathione peroxidase, a major intracellular antioxidant enzyme, through a mechanism that depends on an alteration of the intracellular redox potential (Kokame et al, 1996

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Lipid metabolism, which involves the synthesis and degradation of lipids, plays a vital role in cellular homeostasis, and disruptions in lipid metabolism are associated with various pathological conditions

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PMID: 215 ZeinalabediniMShapouriMMirzaeePKamaliMMahmoudiZNorianiNet al

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