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Kouli A, Torsney KM, Kuan W-L (2018) Parkinsons disease: etiology, neuropathology, and pathogenesis

The Met hydroxy analogs 2-hydroxy-4-(methylthio) butanoic acid (called HMB or HMTBa) and isopropyl ester of 2-hydroxy-4-(methylthio) butanoic acid (HMBi) have been widely used as a precursor of methionine in ruminant nutrition (Noftsger et al., 2003)

& Whalen, M

Chronic studies in rats given 200 mg/kg body weight per day for 104 weeks, dogs given 20 mg/kg PO x 84 days, cats given 40-65 mg/kg for 118 days did not produce any signs of toxicity (blood testing, liver histology)