Intravenous injection of succinate into rats and mice induces hypertension via activation of the reninangiotensin system, and this response is abolished in GPR91-deficient mice 89
The findings, published in Diabetes Care , also show the reduction in MACEs a combination of heart attacks, stroke, or death from cardiovascular causes isnt due to the drugs effect in lowering blood sugar
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TW has received travel support from Novartis and Sanofi and research funding from Novartis and AstraZeneca
As an NNMT inhibitor, it enhances NAD+ availability