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Deposition of cholesterol in the intima of arteries induces endothelium to produce VCAM-1 50 which appears to be cytokine dependent as the presence of TNF- in the smooth muscle cells is associated with an increase expression of VCAM-1 51

Overall, the actions of Semaglutide help to improve glycemic control, lower blood sugar levels, and promote weight loss in individuals with type 2 diabetes