doi:10.1016/j.jchf.2022.07.013
Genetically modified folate overproducing strains of some fungi and bacteria have been constructed, e.g., Ashbya gossypii , Escherichia coli , and Bacillus subtilis , the first being the best folate producer reported to date with folate titers of 6.6 mg/L (i.e., 146-fold higher than the wild strain) 631,632,633,634
However, it is also essential to identify a dose that can induce pharmacologic activity in subsequent studies
GSH may also play a role in the recycling of antioxidants like vitamin C
In this study, the investigator assessing photographs was blinded, but patients knew whether they received the active serum or saline