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Indeed, Soares and colleagues report that four hours after a single excess dose of APAP, adult mice brains exhibit mitochondrial dysfunction and oxidative stress 85

Evaporation is a distillation process that produces nearly pure water with almost no dissolved ions

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Notably, although co-administration with minocycline improves mechanical allodynia by suppressing microglial activation, it exerts no significant alleviation of cold allodynia (236), underscoring the pathway-specific nature of duloxetines analgesic actions

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