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In a comparative study the size dependency of BBB uptake and permeability was investigated for nanoparticles from 50 to 500 nm of various composition (polystryrene, protein, lipid) on a human culture BBB model in which transferrin nanocarriers with 500 nm diameter showed the most successful BBB penetration [61]
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Whilst the individual components (methionine, inositol, choline) play roles in lipid metabolism, there are no large-scale, peer-reviewed studies demonstrating that injectable formulations produce clinically meaningful weight loss or metabolic benefits
The safety and efficacy of liraglutide with or without oral antidiabetic drug therapy in type 2 diabetes: an overview of the LEAD 1-5 studies
