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Discovery of 2-[3, 5-dichloro-4-(5-isopropyl-6-oxo-1, 6-dihydropyridazin-3-yloxy) phenyl]-3, 5-dioxo-2, 3, 4, 5-tetrahydro [1, 2, 4] triazine-6-carbonitrile (MGL-3196), a highly selective thyroid hormone receptor agonist in clinical trials for the treatment of dyslipidemia
However, STP2 , a transcription factor that regulates expression of amino acid permeases seemed to play an important role given that a stp2 mutant showed attenuated cytotoxic potential (Fig
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Evidence of a role for one-carbon metabolism in blood pressure: can B vitamin intervention address the genetic risk of hypertension owing to a common folate polymorphism
Published 2022
